Research indicates there is a higher prevalence of autism spectrum conditions among transgender individuals compared to the general population, though the reasons for this overlap remain under investigation. Studies suggest that whilst some people are both autistic and transgender, autism itself does not cause gender dysphoria, nor does being transgender indicate autism.

Evidence shows that this association is sometimes misused to question the validity of transgender identities or to delay gender-affirming care. However, guidelines from major medical organisations emphasise that autism should not be considered a contraindication for gender support. People who are transgender may share certain characteristics with those who are autistic, particularly if they have experienced social difficulties or marginalisation, but this does not diminish the authenticity of their gender identity.

Current best practice recognises that some individuals may be both autistic and transgender, and both aspects of their identity deserve appropriate support and understanding. Mental health professionals are trained to assess each person individually, considering all aspects of their wellbeing rather than using one condition to invalidate another.