Research shows that hormone therapy can provide significant benefits for transgender teenagers, even after they have experienced puberty that doesn't align with their gender identity. Evidence indicates that whilst some physical changes from unwanted puberty cannot be fully reversed, hormone therapy can effectively halt further unwanted development and begin the process of helping the body align more closely with a person's gender identity.

Guidelines recommend that hormone therapy for transgender teenagers focuses on both physical and psychological wellbeing. For transgender girls who have experienced male puberty, oestrogen therapy can support feminisation, including changes in fat distribution and other secondary sexual characteristics. Medical research demonstrates that the psychological benefits are often particularly pronounced, with many young people experiencing improved mental health and social engagement.

Studies consistently show that transgender teenagers who had previously withdrawn from social activities, experienced communication difficulties, or avoided public spaces often begin to re-engage with the world around them as their bodies start to develop in alignment with their gender identity. The combination of physical changes and psychological relief can be transformative for overall quality of life and mental health outcomes.